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Overcoming Barriers to Genomic Medicine Implementation
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Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry
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Audio Summary January 2025
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Untargeted Metabolomics for Inborn Errors of Metabolism: Development and Evaluation of a Sustainable Reference Material for Correcting Inter-Batch Variability
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Novel In-Line Hemolysis Detection on a Blood Gas Analyzer and Impact on Whole Blood Potassium Results
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Forever Chemicals, Endless Testing? Expert Advice to Be Prepared for Per- and Polyfluoroalkyl Substances
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Audio Summary December 2024
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Alzheimer disease blood-based biomarkers: Translation from research into clinical use
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Deconvolution of human urine across the transcriptome and metabolome
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Niacin and Risk of Cardiovascular Events: Deciphering the Paradox
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Audio Summary November 2024
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Approval of the First CRISPR-Cas9 Gene Editing Therapy for Sickle Cell Disease
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Personalized Reproductive Hormone Monitoring in Sweat
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Reference Intervals Revisited: A Novel Model for Population-Based Reference Intervals, Using a Small Sample Size and Biological Variation Data
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Beyond the Screen: Navigating Remote Work within Medicine
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Audio Summary October 2024
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ChatGPT vs Medical Professional: Analyzing Responses to Laboratory Medicine Questions on Social Media
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Congenital Syphilis: An Emerging, Preventable Public Health Crisis
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The Era of Early Detection and Treatment of Brain Amyloid Deposition in Asymptomatic Individuals?
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Audio Summary September 2024
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Clinical Laboratories Confront a New Wave of Drug Overdose Deaths
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Audio Summary August 2024
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Osmotic Demyelination Syndrome in Hyponatremia: Does the Rate of Sodium Correction Matter?
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Breaking Boundaries: Exploring Performance Enhancement and Anti-Doping Testing in Sports
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Use of Maternal Race and Weight Provides Equitable Performance in Serum Screening for Open Neural Tube Defects
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Audio Summary July 2024
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Biological Insights from Cell-Free DNA Methylome Analysis in Preeclampsia
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Microbiome-Based Diagnostics for Disease: Where Are We Now and Where Are We Headed?
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Biomarkers vs Machines: The Race to Predict Acute Kidney Injury
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Audio Summary June 2024
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Evaluation of Nanopore Sequencing on Polar Bodies for Routine Pre-Implantation Genetic Testing for Aneuploidy
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Challenges Associated with the Effective Implementation of New Laboratory Tests—The International Experience
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Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals?
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Audio Summary May 2024
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Large Language Models for Scientific Publishing: Please, Do Not Make Them a Foe
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Eye Catching Advancement for Creutzfeldt–Jakob Disease Diagnostics
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More Than a Decade of Rapid Genomic Sequencing: Where Are We Now?
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Audio Summary April 2024
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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
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The Next Clinical Decision Frontier: How to Efficiently and Safely Combine Machine Learning and Human Expertise
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Clinical Decision Support in Laboratory Medicine
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Audio Summary March 2024
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New Sepsis Diagnostics and Their Impacts on Clinical Decision-Making and Treatment Protocols
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Transport of Full-Length Proteins through a Nanopore: One Step Closer to Single-Molecule Proteomics
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Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning
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Screening in Multiple Myeloma and Its Precursors: Are We There Yet?
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Eight Misconceptions about Prostate-Specific Antigen
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Cancer Screening, Incidental Detection, and Overdiagnosis
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Audio Summary February 2024
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Reevaluating the Role of High-Density Lipoprotein Cholesterol: New Perspectives on Cardiovascular Disease and Alzheimer Disease
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Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age
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Audio Summary January 2024
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Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography–Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study
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Audio Summary December 2023
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Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays
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AI Chatbots in Clinical Laboratory Medicine: Foundations and Trends
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Generalizability of a Machine Learning Model for Improving Utilization of Parathyroid Hormone-Related Peptide Testing across Multiple Clinical Centers
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Audio Summary November 2023
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Confirmation of Insertion, Deletion, and Deletion-Insertion Variants Detected by Next-Generation Sequencing
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Generative Artificial Intelligence: More of the Same or Off the Control Chart?
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Short Timeframe Prediction of Kidney Failure among Patients with Advanced Chronic Kidney Disease
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Audio Summary October 2023
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Reference Interval Harmonization: Harnessing the Power of Big Data Analytics to Derive Common Reference Intervals across Populations and Testing Platforms
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A Machine Learning Model for the Routine Detection of “Wrong Blood in Complete Blood Count Tube” Errors
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In-Hospital Manufacturing of Cellular Therapies Using Automated Systems
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Audio Summary September 2023
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Feasibility of Targeted Next-Generation DNA Sequencing for Expanding Population Newborn Screening
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Abatacept as a Mimic of Gamma Heavy Chain Disease
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Assessing the Accuracy and Clinical Utility of ChatGPT in Laboratory Medicine
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Audio Summary August 2023
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Machine Learning in Laboratory Medicine: Recommendations of the IFCC Working Group
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Driving Under the Influence of Cannabis: Impact of Combining Toxicology Testing with Field Sobriety Tests
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Tissue Mass Spectrometry: How Solid Is Our Future?
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Audio Summary July 2023
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Polygenic Risk Scores: Genomes to Risk Prediction
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Rapid Rule-Out of Myocardial Infarction Using a Single High-Sensitivity Cardiac Troponin I Measurement Strategy at Presentation to the Emergency Department: The SAFETY Study
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Using Biomarkers for Traumatic Brain Injury: Are There Lessons That Can Be Learned from Implementing Cardiac Troponin?
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Audio Summary June 2023
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The Present and Future of Lipid Testing in Cardiovascular Risk Assessment
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Multiplexing Homocysteine into First-Tier Newborn Screening Mass Spectrometry Assays Using Selective Thiol Derivatization
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Lab Medicine in Space
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Audio Summary May 2023
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FDA Regulation of Laboratory Clinical Decision Support Software: Is It a Medical Device?
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The Genotype—Phenotype Conundrum for Antimicrobial Susceptibility Testing
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Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?
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Audio Summary April 2023
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Clinical Perspective on Use of Long-Read Sequencing in Prenatal Diagnosis of Thalassemia
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Effects of Supplemented Mediterranean Diets on Plasma-Phospholipid Fatty Acid Profiles and Risk of Cardiovascular Disease after 1 Year of Intervention in the PREDIMED Trial
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A Spotlight on Disruptors and Innovators
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Audio Summary March 2023
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Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis
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Laboratory Preparedness for the Current Monkeypox Outbreak
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Within-Person and Between-Sensor Variability in Continuous Glucose Monitoring Metrics
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A Translational Tool to Facilitate Use of Apolipoprotein B for Clinical Decision-Making
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Audio Summary February 2023
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Neutral-Coating Capillary Electrophoresis Coupled with High-Resolution Mass Spectrometry for Top-Down Identification of Hemoglobin Variants
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One Bad Apple Can Spoil the Bunch: The Impact of Contamination in the Clinical Laboratory
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Can Rapid Nanopore Sequencing Bring Genomic Testing to the Bedside?
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What is the Importance of Analyzing Tumor Tissues and Blood Cells in the Study of Circulating Tumor-Derived DNA?
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Audio Summary January 2023
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